Jiake Xu Selected Research

Osteolysis

1/2022	Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling.
1/2022	Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis.
10/2021	The molecular structure and role of CCL2 (MCP-1) and C-C chemokine receptor CCR2 in skeletal biology and diseases.
1/2021	Inhibitory effects of biochanin A on titanium particle-induced osteoclast activation and inflammatory bone resorption via NF-κB and MAPK pathways.
1/2021	Single-Cell RNA Sequencing Reveals the Migration of Osteoclasts in Giant Cell Tumor of Bone.
1/2021	Carnosol suppresses RANKL-induced osteoclastogenesis and attenuates titanium particles-induced osteolysis.
1/2021	Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma.
1/2019	Daphnetin attenuates LPS-induced osteolysis and RANKL mediated osteoclastogenesis through suppression of ERK and NFATc1 pathways.
1/2019	Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo.
1/2019	Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice.

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Jiake Xu Research Topics

Disease

74	Bone Resorption 12/2022 - 04/2003
49	Neoplasms (Cancer) 01/2022 - 08/2003
37	Osteoporosis 12/2022 - 09/2011
27	Osteolysis 01/2022 - 11/2004
20	Bone Diseases (Bone Disease) 01/2022 - 11/2004
13	Inflammation (Inflammations) 12/2022 - 02/2009
8	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 01/2018
7	Rheumatoid Arthritis 10/2021 - 04/2015
7	Arthritis (Polyarthritis) 02/2020 - 02/2009
6	Neoplasm Metastasis (Metastasis) 01/2022 - 08/2003
6	Breast Neoplasms (Breast Cancer) 03/2021 - 01/2016
6	Osteitis Deformans (Paget's Disease of Bone) 01/2021 - 07/2006
6	Osteoarthritis 01/2020 - 06/2013
5	Postmenopausal Osteoporosis 12/2022 - 11/2015
5	Spinal Cord Injuries (Spinal Cord Injury) 03/2022 - 01/2019
4	Giant Cell Tumor of Bone 01/2022 - 08/2003
3	Metabolic Bone Diseases (Osteopenia) 01/2021 - 01/2017
3	Osteonecrosis (Kienbock's Disease) 01/2020 - 06/2013
3	Infections 01/2019 - 05/2016
3	Experimental Arthritis 11/2018 - 05/2013
2	Periodontitis 12/2021 - 02/2009
2	Osteopetrosis 01/2021 - 01/2016
2	Cerebral Hemorrhage 01/2021 - 01/2020
2	Hypoxia (Hypoxemia) 01/2021 - 01/2020
2	Pain (Aches) 01/2019 - 01/2016
2	Carcinogenesis 11/2018 - 03/2018
2	Bone Fractures (Bone Fracture) 03/2018 - 01/2016
2	Melanoma (Melanoma, Malignant) 01/2018 - 10/2015
2	Congenital Abnormalities (Deformity) 01/2018 - 01/2017
2	Multiple Myeloma 09/2017 - 08/2009
2	Hemolysis 02/2017 - 09/2015
2	Malaria 01/2017 - 01/2016
2	Wounds and Injuries (Trauma) 01/2017 - 01/2014

Drug/Important Bio-Agent (IBA)

19	Pharmaceutical PreparationsIBA 01/2022 - 08/2012
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2004
12	LigandsIBA 05/2022 - 08/2003
9	Estrogens (Estrogen)FDA Link 06/2022 - 11/2015
9	Therapeutic UsesIBA 10/2021 - 02/2009
9	Tartrate-Resistant Acid PhosphataseIBA 01/2021 - 11/2016
8	CalciumIBA 05/2022 - 09/2007
7	TitaniumIBA 01/2022 - 01/2015
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2013
7	LipopolysaccharidesIBA 01/2019 - 11/2004
6	FlavonoidsIBA 01/2022 - 09/2011
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 12/2018
6	Biological ProductsIBA 01/2021 - 01/2009
6	AntioxidantsIBA 12/2019 - 01/2016
5	Durapatite (Hydroxylapatite)IBA 01/2022 - 06/2015
5	RNA (Ribonucleic Acid)IBA 01/2022 - 10/2020
5	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2018
5	NF-kappa B (NF-kB)IBA 12/2009 - 11/2004
4	Messenger RNA (mRNA)IBA 12/2022 - 08/2003
4	parthenolideIBA 06/2022 - 11/2004
4	RANK LigandIBA 01/2021 - 08/2006
4	Mitogen-Activated Protein KinasesIBA 01/2020 - 07/2014
4	Cathepsin KIBA 01/2020 - 09/2007
4	MicroRNAs (MicroRNA)IBA 12/2019 - 06/2015
4	Adenosine Triphosphatases (ATPase)IBA 12/2019 - 04/2003
3	LuciferasesIBA 05/2022 - 01/2015
3	Actins (F Actin)IBA 01/2022 - 01/2019
3	HydrogelsIBA 12/2021 - 01/2017
3	UbiquitinIBA 01/2021 - 08/2006
3	SesquiterpenesIBA 01/2019 - 11/2004
3	CytokinesIBA 01/2019 - 05/2015
3	Polysaccharides (Glycans)IBA 12/2018 - 01/2018
3	Docetaxel (Taxotere)FDA Link 02/2017 - 09/2015
3	CollagenIBA 01/2017 - 01/2014
3	Small Interfering RNA (siRNA)IBA 01/2017 - 01/2016
3	Protein Kinase CIBA 06/2015 - 12/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2016
2	TriterpenesIBA 01/2022 - 01/2019
2	Lysine (L-Lysine)FDA Link 01/2021 - 01/2016
2	Protein Kinases (Protein Kinase)IBA 01/2021 - 01/2020
2	Sorting NexinsIBA 01/2021 - 01/2016
2	Long Noncoding RNAIBA 11/2020 - 01/2020
2	IntegrinsIBA 12/2019 - 01/2019
2	Opioid Analgesics (Opioids)IBA 01/2019 - 01/2016
2	Bone Density Conservation AgentsIBA 01/2019 - 01/2017
2	LactonesIBA 01/2019 - 11/2004
2	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2019 - 01/2016
2	polyglycerolIBA 10/2018 - 01/2016
2	Folic Acid (Vitamin M)FDA LinkGeneric 10/2018 - 01/2016
2	Nerve Growth Factors (Neurotrophins)IBA 03/2018 - 01/2016
2	Carrier Proteins (Binding Protein)IBA 01/2018 - 02/2014
2	Diphosphonates (Bisphosphonates)IBA 01/2018 - 01/2017
2	ArtesunateIBA 01/2018 - 01/2017
2	Peptides (Polypeptides)IBA 01/2018 - 06/2015
2	Choline KinaseIBA 01/2017 - 01/2015
2	Phosphotransferases (Kinase)IBA 01/2017 - 09/2007
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 11/2016 - 09/2007
2	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 10/2016 - 01/2016
2	AntigensIBA 10/2015 - 05/2013
2	Aspartic Acid (Aspartate)FDA Link 06/2015 - 03/2006
2	GlucocorticoidsIBA 05/2015 - 05/2013

Therapy/Procedure

34	Therapeutics 12/2021 - 08/2009
11	Ovariectomy (Oophorectomy) 05/2022 - 11/2015
5	Drug Therapy (Chemotherapy) 01/2019 - 07/2012
3	Arthroplasty 01/2022 - 01/2019
3	Complementary Therapies (Alternative Medicine) 01/2017 - 09/2011
2	Injections 12/2021 - 01/2020